Very vaguely based upon the 1988 movie, this cartoon series featured the repulsive ghost Beetlejuice [Stephen Ouimette] in his Neitherworld exploits. His only friend on Earth, Lydia Deitz [Alyson Court], a goth who came from a rather normal family, called upon Beetlejuice by uttering his name three times. Beetlejuice took pleasure in haunting people and causing trouble in the real world town of Peaceful Pines - especially toward Lydia's unsuspecting parents: Charles Deetz and her ditzy mother Delia Deetz.

The show never spared a single "crunch" sound effect whenever he bit into a roach (which usually crawled out of his hair whenever he scratched his head). Back at home in the surreal looking Neitherworld, each episode would feature a cutscene of some sort (usually when Beetlejuice watches "a little TV", literally a 5" tall TV set), the cartoon would cut to a stop-frame animation 'tv commercial' that was created by animators at Calibre Digital Pictures. Beetlejuice's main concern were the deadly tower-sized Sandworms, drawn in alternating white and black stripes that are so well known for Burton's style.

The series spanned 4 seasons: first on ABC's Saturday morning lineup in 1988, and concluding as a weekday afternoon program on FOX, up until 1991. Episodes of the animated series "Beetlejuice" appeared briefly on VHS home release.