Dennis the Menace was an early weekday afternoon cartoon re-hashing the characters of the 1959 television show and comics of the same name.

Each episode started off with a blaring saxophone intro and featured the sometimes wreckless child Dennis Mitchell [Brennan Thicke] and his own adventures and exploits around town with his shaggy pet dog Ruff [voiced by Phil Hartman]. The late Phil Hartman of SNL fame also voiced George Wilson, Dennis' elderly next door neighbor who had a short fuse but genuinely a kind heart. His patient wife, Martha Wilson [Marilyn Lightstone] always seemed to overlook Dennis' mischevious nature, no matter how many times he broke her fence or trampled her flowers. Other characters on the show included nerdy looking Margaret [Jeannie Elias] who constantly attempted to boss Dennis around, and Dennis' mild mannered parents, Henry [Phil Hartman] and Alice [Marilyn Lightstone]. The series also introduced new characters such as Dennis' friends Joey and Peebee.

MGM released various episodes of the animated "Dennis the Menace" series on DVD in 2003.