"Ghostbusters" was a syndicated animated series based on the live-action 1975 television series, "The Ghost Busters." Also known as "Original" or "Filmation's" Ghostbusters, this series featured Jake [Pat Fraley], Eddie [Peter Cullen], and Tracey the safari-hat wearing gorilla [voiced by Lou Scheimer], a trio of ghost hunters stationed at the Ghost Command, with their time travelling friend Futura [Susan Blu], newspaper reporter Jessica Ray[Susan Blu], and the pink colored bat Belfry. Calls came into the station via Ansa-Bone, an animated, skull-shaped telephone who is typically impatient and tired of explaining the Ghostbuster's insubordination. When preparing for adventure, the Ghostbusters slide across the floor into their transformation chamber - a bone-lined cabinet that somehow arms and equips them, resulting in a series of wacky events where they bounce and flip around before landing inside of the Ghost Buggy. Armed with "de-materializer" guns (or a host of other strange contraptions) and their rickety, seemingly 'alive' Ghost Buggy, they patrolled the city and extinguished ghosts, which were simply transported back to their dimension once blasted.

Led by Prime Evil [Alan Oppenheimer] - a leader of the evil ghosts located in the Hauntquarters of the Fifth Dimension; the usual crew of ghosts in each episode consisted of his stool pidgeon Brat-A-Rat [Don Francks] - a squeaky and obnoxious floating rat creature, Scared Stiff [Maurice LaMarche] - a flimsy robotic skeleton that typically falls to pieces, Fangster [Alan Oppenheimer] the werewolf, Mysteria [Linda Gary] - a sorceress, Fib-Face [Frank Welker] and his multiple faces, and Haunter - who resembles a turn-of-the-century poacher, Long John Scarechrome [Neil Ross] a pirate themed ghost, Sir Trance-a-Lot - a ghastly jouster riding his horse Frightmare, Apparitia - another female specter, and the mummy Airhead.

At the end of each episode, a moral or lesson was dictated by one of the characters (usually Jake, Ansa-Bone, Belfry or Jessica) in typical Filmation fashion. The drawing style of this animated series very closely resembles that of "He-Man and the Masters of the Universe," "Bravestarr," and other such Filmation series at the time.

The Ghostbusters theme song was an instrumental, except for a repeating chorus of "Let's Go, Ghostbusters, Let's Go!"

• This animated series was based on a 1975 live-action television series, "The Ghost Busters," which was also the very first show to actually claim the rights to that phrase.
• This series was the beginning of what would become a legal (and popularity) battle between Filmation Associates and Colombia Pictures. Colombia was legally able to use the word "Ghostbusters," prompting Filmation to re-vamp their 1975 series as an animation. In response, Colombia released their own animated version of the 1984 movie Ghostbusters with the word "Real" heavily emphasized (as can be seen in the opening sequence) of The Real Ghostbusters.