Dog-pound resident puppies break free with the help of a young orphan, Holly [Ami Foster], and scatter from Holly's guardian Katrina [Pat Carroll] and her daughter Brattina [Adrienne Alexander]. The puppies: Howler [Robert Morse], Cooler [Dan Gilvezan], Bright Eyes [Nancy Cartwright], Nose Marie [Ruth Buzzi] and Whopper [B.J. Ward] worked to find homes for other abandoned puppies. They also warded off Catgut [Frank Welker] and Nabbit [Frank Welker]. The series later spun off a movie in 1988 entitled "Pound Puppies and the Legend of Big Paw"

Early Season:
This Pound Puppies theme was an instrumental.

Late Seasons:
We're Pound Puppies: Cooler, and the crew
Whopper, Bright Eyes, Nose Marie, helping pup-aroos
For every puppy in town, a happy home will be found
We are Pound Puppies, we’ll find a pup for you

You Pound Puppies, I hate them, yes I do
Eww! Pound Puppies! They’re yucky, icky, poo.
Soon I’ll catch every pup, and, then, I’ll lock ‘em all up
You Pound Puppies, your rebel days are through!

We're Pound Puppies, we're loving and true blue
Yo Pound Puppies, with puppy power too
For every puppy we pet, a happy home he will get
We're Pound Puppies, we wanna...go...home...with...you!

Howler: "Aooooo..."
All: "Please take us home!"

The Pound Puppies line of stuffed animals was highly successful and produced by Tonka in 1985 - the same year as the very first Pound Puppies television special aired before the actual series.